Saffron for Mood: Natural Support for Calm and Emotional Resilience

Feeling anxious, low, or irritable? Saffron extract is a natural, research-backed option that may help support mood, emotional regulation, and overall mental well-being.

Why Families Are Interested

• Enhances mood and emotional resilience through plant-based compounds

• Supports neurotransmitter balance for calm and focus
  Protects brain cells and reduces inflammation affecting mood

Who Might Benefit

• Anyone experiencing stress, anxiety, or emotional ups and downs

• Individuals looking for natural, integrative support alongside therapy or lifestyle strategies

Saffron is a gentle, plant-based boost for mood and calm, easily integrated into a personalized integrative plan that fits your family’s needs.

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References

1. An Examination Into the Effects of a Saffron Extract (Affron) on Mood and General Wellbeing in Adults Experiencing Low Mood: A Randomized, Double-Blind, Placebo-Controlled Trial. Lopresti AL, Smith SJ, Marx W, Díez-Municio M, Morán-Valero MI. J Nutr. 2025;155(7):2300-2311. doi:10.1016/j.tjnut.2025.05.024. New Research
2. New Horizons for the Study of Saffron (Crocus Sativus L.) and Its Active Ingredients in the Management of Neurological and Psychiatric Disorders: A Systematic Review of Clinical Evidence and Mechanisms. Han S, Cao Y, Wu X, et al. Phytother Res. 2024;38(5):2276-2302. doi:10.1002/ptr.8110. Leading Journal
3. Safety and Efficacy of Saffron (Crocus Sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-Analysis. Dai L, Chen L, Wang W. J Nerv Ment Dis. 2020;208(4):269-276. doi:10.1097/NMD.0000000000001118.
4. Effect of Saffron Supplementation on Symptoms of Depression and Anxiety: A Systematic Review and Meta-Analysis. Marx W, Lane M, Rocks T, et al. Nutr Rev. 2019;77(8):557-571. doi:10.1093/nutrit/nuz023. Leading Journal
5. The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-Analysis. Tóth B, Hegyi P, Lantos T, et al. Planta Med. 2019;85(1):24-31. doi:10.1055/a-0660-9565.
6. Saffron, as an Adjunct Therapy, Contributes to Relieve Depression Symptoms: An Umbrella Meta-Analysis. Musazadeh V, Zarezadeh M, Faghfouri AH, et al. Pharmacol Res. 2022;175:105963. doi:10.1016/j.phrs.2021.105963. Leading Journal
7. Exploring the Potential of Saffron as a Therapeutic Agent in Depression Treatment: A Comparative Review. Chauhan S, Tiwari A, Verma A, et al. Yale J Biol Med. 2024;97(3):365-381. doi:10.59249/XURF4540.
8. The Effects of Saffron (Crocus Sativus L.) on Mental Health Parameters and C-Reactive Protein: A Meta-Analysis of Randomized Clinical Trials. Ghaderi A, Asbaghi O, Reiner Ž, et al. Complement Ther Med. 2020;48:102250. doi:10.1016/j.ctim.2019.102250.
9. Anti-Depressant Properties of Crocin Molecules in Saffron. Siddiqui SA, Ali Redha A, Snoeck ER, et al. Molecules (Basel). 2022;27(7):2076. doi:10.3390/molecules27072076.
10. Crocus Sativus and Neurological Health: A Review on Depression and Impaired Neurogenesis. Sultana A, Shafeeh AR, Ahmed MG, et al. Curr Pharm Des. 2025;:CPD-EPUB-149887. doi:10.2174/0113816128380974250716232813. New Research
11. The Effects of Combined Scutellaria and Saffron Supplementation on Mood Regulation in Participants With Mild-to-Moderate Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study. Dormal V, Suchareau M, Copine S, Simar L, Deldicque L. Nutrients. 2025;17(5):809. doi:10.3390/nu17050809. New Research
12. Affron, a Standardised Extract From Saffron (Crocus Sativus L.) for the Treatment of Youth Anxiety and Depressive Symptoms: A Randomised, Double-Blind, Placebo-Controlled Study. Lopresti AL, Drummond PD, Inarejos-García AM, Prodanov M. J Affect Disord. 2018;232:349-357. doi:10.1016/j.jad.2018.02.070. Leading Journal